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Tuesday, June 15, 2021

Israel Study (Group That Already Had Covid-19): The Vaccinated Show Eight Times Higher Prevalence Rate for S.Africa’s Variant

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The article is available in Greek here.

JERUSALEM (Times of Israel) – The coronavirus variant discovered in South Africa may evade the protection provided by Pfizer/BioNTech’s Covid-19 vaccine to some extent, a real-world data study in Israel found.

The study, released on Saturday, compared almost 400 people who had tested positive for Covid-19, 14 days or more after they received one or two doses of the vaccine, against the same number of unvaccinated patients with the disease.

It matched age and gender, among other characteristics.

The South African variant, B.1.351, was found to make up about 1% of all the Covid-19 cases across all the people studied, according to the study by Tel Aviv University and Israel’s largest healthcare provider, Clalit.

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But among patients who had received two doses of the vaccine, the variant’s prevalence rate was eight times higher than those unvaccinated – 5.4% versus 0.7%.

Prof. Adi Stern, who headed the research, said to The Times of Israel:“Based on patterns in the general population, we would have expected just one case of the South African variant, but we saw eight […] Obviously, this result didn’t make me happy.”

This suggests the vaccine is less effective against the South African variant, compared with the original coronavirus and a variant first identified in Britain that has come to comprise nearly all Covid-19 cases in Israel, the researchers said.

“We found a disproportionately higher rate of the South African variant among people vaccinated with a second dose, compared to the unvaccinated group. This means that the South African variant is able, to some extent, to break through the vaccine’s protection,” said Tel Aviv University’s Adi Stern.

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The researchers cautioned, though, that the study only had a small sample size of people infected with the South African variant because of its rarity in Israel.

They also said the research was not intended to deduce overall vaccine effectiveness against any variant, since it only looked at people who had already tested positive for Covid-19, not at overall infection rates.

Pfizer, that have shown 100% effectiveness in S. Africa where the variant is prevalent, declined to comment on the Israeli study.

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Pfizer and BioNTech said on April 1 that their vaccine was around 91% effective at preventing Covid-19, citing updated trial data that included participants inoculated for up to six months.

They have been testing a third dose of their shot as a booster, and have said they could modify the shot to specifically address new variants if needed.

In respect to the South African variant, they said that among a group of 800 study volunteers in South Africa, where B.1.351 is widespread, there were nine cases of Covid-19, all of which occurred among participants who got the placebo. Of those nine cases, six were among individuals infected with the South African variant.

Some previous studies have indicated that the Pfizer/BioNTech shot was less potent against the B.1.351 variant than against other variants of the coronavirus, but still offered a robust defence.

The Tel Aviv research appears to corroborate a recent study from Ben-Gurion University of the Negev, which found that the vaccine response is less effective against the South African variant. It drew its conclusion by analyzing blood samples, while the new research is based on actual sequenced test results.

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Variant is not Widespread

While the results of the study may cause concern, the low prevalence of the South African strain was encouraging, according to Tel Aviv University’s Stern.

“Even if the South African variant does break through the vaccine’s protection, it has not spread widely through the population,” said Stern, adding that the British variant may be “blocking” the spread of the South African strain.

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